Following the successful PHM conferences over the past 20 years, the 2021 Prognostics and System Health Management Conference will be held in Nanjing, China, from October 15-17, 2021. PHM is a wide-ranging, interdisciplinary field, that requires an energized exchange of ideas. This conference will match-up world-class expertise in the academic, engineering, and management disciplines to create synergistic exchanges of ideas and practices. Special attention has been paid to assure a sociable and professional atmosphere to encourage networking, forge new relationships, and deepen existing ones. This conference will provide a premier interdisciplinary forum on PHM related topics. All the accepted papers will be published in IEEE Xplore® and indexed by Engineering Index (EI). Selected excellent papers will be published in a special issue.